In this paper, we evaluate the competitiveness of electric commercial vehicle (ECV) in medium-duty mid-haul logistics for a specific case study. This is done combining an aggregated total cost of ownership analysis with an integrated location-routing model with simultaneous locating of charging stations at stores and multi-shift, multi-period pickup and delivery routing of vehicles within the logistics network. This allows for a fair comparison of electric commercial vehicle and internal combustion engine vehicle. Results show that nearly no operational limitations arise by electrifying the mid-haul logistics fleet for this specific case. Moreover, electric commercial vehicle show clear advantages in this case with regard to total costs and emission savings. Based on these positive results, managerial insights are derived for logistics fleet operators.