In One-to-Many-to-One Single Vehicle Pickup and Delivery Problems a vehicle based at the depot must make deliveries and pickups at customers locations before returning to the depot. Several variants can be defined according to the demand structures and sequencing rules imposed on pickups and deliveries. In recent years there has been an increased interest in this family of problems. New formulations and efficient heuristics capable of yielding general solutions (unrestricted in shape) have been proposed. In addition, some new and interesting extensions have been analyzed, including problems with selective pickups and problems with capacitated customers. The purpose of this chapter is to review these developments.